A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma.

ABSTRACT: Rationale: MicroRNAs are potent regulators of biologic systems that are critical to tissue homeostasis. Individual microRNAs have been identified in airway samples. However, a systems analysis of the microRNA-mRNA networks present in the sputum that contribute to airway inflammation in asthma has not been published.Objectives: Identify microRNA and mRNA networks in the sputum of patients with asthma.Methods: We conducted a genome-wide analysis of microRNA and mRNA in the sputum from patients with asthma and correlated expression with clinical phenotypes. Weighted gene correlation network analysis was implemented to identify microRNA networks (modules) that significantly correlate with clinical features of asthma and mRNA expression networks. MicroRNA expression in peri

SUBMITTER: Gomez JL 

PROVIDER: S-EPMC7328332 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature