The Prevalence and Determinants of Neuropsychiatric Symptoms in Late-Stage Parkinsonism.

ABSTRACT:

Background

Late-stage parkinsonism and Parkinson's disease (PD) are insufficiently studied population. Although neuropsychiatric symptoms (eg, psychosis, depression, anxiety, behavioral problems) are frequently present, their prevalence and clinical predictors remain unknown.

Objective

To determine the prevalence and predictors of neuropsychiatric symptoms in late-stage PD.

Methods

We conducted a multinational study of patients with PD with ≥7 years disease duration and either a Hoehn and Yahr stage ≥4 or a Schwab and England score ≤ 50% in the on stage. Neuropsychiatric symptoms were assessed through interviews with carers using the Neuropsychiatric Inventory, with a frequency × severity score ≥ 4, indicating clinically relevant symptoms. The determinants anal

SUBMITTER: Hommel ALAJ 

PROVIDER: S-EPMC7328429 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature