Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas.

ABSTRACT: Direct lineage reprogramming of abundant and accessible cells into therapeutically useful cell types holds tremendous potential in regenerative medicine. To date, a number of different cell types have been generated by lineage reprogramming methods, including cells from the neural, cardiac, hepatic, and pancreatic lineages. The success of this strategy relies on developmental biology and the knowledge of cell-fate-defining transcriptional networks. Hepatocytes represent a prime target for β cell conversion for numerous reasons, including close developmental origin, accessibility, and regenerative potential. We present here an overview of pancreatic and hepatic development, with a particular focus on the mechanisms underlying the divergence between the two cell lineages. Additionally, we di

SUBMITTER: Ruzittu S 

PROVIDER: S-EPMC7328458 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature