Functional angiogenesis requires microenvironmental cues balancing endothelial cell migration and proliferation.

ABSTRACT: Angiogenesis is a complex morphogenetic process that involves intimate interactions between multicellular endothelial structures and their extracellular milieu. In vitro models of angiogenesis can aid in reducing the complexity of the in vivo microenvironment and provide mechanistic insight into how soluble and physical extracellular matrix cues regulate this process. To investigate how microenvironmental cues regulate angiogenesis and the function of resulting microvasculature, we multiplexed an established angiogenesis-on-a-chip platform that affords higher throughput investigation of 3D endothelial cell sprouting emanating from a parent vessel through defined biochemical gradients and extracellular matrix. We found that two fundamental endothelial cell functions, migration and prolifera

SUBMITTER: Wang WY 

PROVIDER: S-EPMC7328820 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature