Using contact statistics to characterize structure transformation of biopolymer ensembles.

ABSTRACT: As a unique subset of functional polymers, many biopolymers have a set of well-defined three-dimensional (3D) structural characteristics that can be described by spatial contacts between monomers. Statistical analysis of the contacts has been extremely productive in characterizing the biopolymer structural ensemble, such as for 3D chromosome structures. Often, native contacts and compartment structures are the focus of the studies, while the generic polymer aspect, such as the overall decaying of contacts with increasing sequence distance, is analyzed separately or preemptively removed. Here, we explore insights that can be gained by performing "compartment analysis" that keeps the distance decay, which we believe is particularly useful for characterizing the structure transformation of bi

SUBMITTER: Das P 

PROVIDER: S-EPMC7329163 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature