Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD.

ABSTRACT:

Background

Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil counts are widely studied but few studies have examined the prognostic value of blood neutrophil counts (BNC).

Methods

In a large population-based COPD registry in the East of Scotland (TARDIS: Tayside Allergic and Respiratory Disease Information System), BNC were compared to measures of disease severity and mortality for up to 15 years follow-up. Potential mechanisms of disease modification by BNC were explored in a nested microbiome substudy.

Results

178,120 neutrophil counts were obtained from 7220 people (mean follow up 9 years) during stable dise

SUBMITTER: Lonergan M 

PROVIDER: S-EPMC7329438 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature