Reduced auditory steady state responses in autism spectrum disorder.

ABSTRACT:

Background

Auditory steady state responses (ASSRs) are elicited by clicktrains or amplitude-modulated tones, which entrain auditory cortex at their specific modulation rate. Previous research has reported reductions in ASSRs at 40 Hz for autism spectrum disorder (ASD) participants and first-degree relatives of people diagnosed with ASD (Mol Autism. 2011;2:11, Biol Psychiatry. 2007;62:192-197).

Methods

Using a 1.5 s-long auditory clicktrain stimulus, designed to elicit an ASSR at 40 Hz, this study attempted to replicate and extend these findings. Magnetencephalography (MEG) data were collected from 18 adolescent ASD participants and 18 typically developing controls.

Results

The ASSR localised to bilateral primary auditory regions. Regions of interest were thus defined

SUBMITTER: Seymour RA 

PROVIDER: S-EPMC7329477 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature