Genomic profiling of colorectal cancer with isolated lung metastasis.

ABSTRACT:

Background

Metastasis is a major cause of failed colorectal cancer (CRC) treatment. While lung metastasis (LM) is observed in 10-15% of patients with CRC, the genetic mechanisms that cause CRC to metastasize to the lung remain unclear.

Methods

In this study, we employed whole exome sequencing (WES) of primary CRC tumors and matched isolated LM lesions to compare their genomic profiles. Comprehensive genomic analyses of five freshly frozen primary tumor lesions, five paired LM lesions, and matched non-cancerous tissues was achieved by WES.

Results

An integrated analysis of somatic mutations, somatic copy number alterations, and clonal structures revealed that genomic alterations were present in primary and metastatic CRCs with various levels of discordance, indicating

SUBMITTER: Zhang N 

PROVIDER: S-EPMC7329491 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature