Fast computation of genome-metagenome interaction effects.

ABSTRACT:

Motivation

Association studies have been widely used to search for associations between common genetic variants observations and a given phenotype. However, it is now generally accepted that genes and environment must be examined jointly when estimating phenotypic variance. In this work we consider two types of biological markers: genotypic markers, which characterize an observation in terms of inherited genetic information, and metagenomic marker which are related to the environment. Both types of markers are available in their millions and can be used to characterize any observation uniquely.

Objective

Our focus is on detecting interactions between groups of genetic and metagenomic markers in order to gain a better understanding of the complex relationship between environm

SUBMITTER: Guinot F 

PROVIDER: S-EPMC7329492 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature