Evidence That Emmetropization Buffers Against Both Genetic and Environmental Risk Factors for Myopia.

ABSTRACT:

Purpose

To test the hypothesis that emmetropization buffers against genetic and environmental risk factors for myopia by investigating whether risk factor effect sizes vary depending on children's position in the refractive error distribution.

Methods

Refractive error was assessed in participants from two birth cohorts: Avon Longitudinal Study of Parents and Children (ALSPAC) (noncycloplegic autorefraction) and Generation R (cycloplegic autorefraction). A genetic risk score for myopia was calculated from genotypes at 146 loci. Time spent reading, time outdoors, and parental myopia were ascertained from parent-completed questionnaires. Risk factors were coded as binary variables (0 = low, 1 = high risk). Associations between refractive error and each risk factor were estimate

SUBMITTER: Pozarickij A 

PROVIDER: S-EPMC7329625 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature