Integrated approaches to reveal mechanisms by which RNA viruses reprogram the cellular environment.

ABSTRACT: RNA viruses are major threats to global society and mass outbreaks can cause long-lasting damage to international economies. RNA and related retro viruses represent a large and diverse family that contribute to the onset of human diseases such as AIDS; certain cancers like T cell lymphoma; severe acute respiratory illnesses as seen with COVID-19; and others. The hallmark of this viral family is the storage of genetic material in the form of RNA, and upon infecting host cells, their RNA genomes reprogram the cellular environment to favor productive viral replication. RNA is a multifunctional biomolecule that not only stores and transmits heritable information, but it also has the capacity to catalyze complex biochemical reactions. It is therefore no surprise that RNA viruses use this functi

SUBMITTER: Haddad C 

PROVIDER: S-EPMC7329689 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature