Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs^-/- mice and thrombosis-prone CBS^-/- humans.

ABSTRACT: Cystathionine β-synthase (CBS)-deficient patients are prone to vascular thrombosis. In contrast, Cbs^-/- mice show no abnormalities in blood coagulation. To identify molecular basis underlying these disparately different thrombotic phenotypes, we analyzed plasma proteomes of Cbs^-/- vs. Cbs^+/+ mice (8-month-old, 12/group, sex-matched) and CBS^-/- vs. CBS^+/+ humans (37 ± 7-year-old, 10-14/group, sex-matched) using label-free mass spectrometry. We identified 117 and 41 differentiating plasma proteins in Cbs^-/- mice and CBS^-/- humans, respectively. Twenty-one proteins were shared between CBS^-/- humans and Cbs^-/- mice, with sixteen changed in the opposite direction. Proteins involved in blood coagul

SUBMITTER: Sikora M 

PROVIDER: S-EPMC7329814 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature