Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions.

ABSTRACT: Indium compounds have been widely used in manufacturing displays of mobile phones, computers and televisions. However, inhalation exposure to indium compounds causes interstitial pneumonia in exposed workers and lung cancer in experimental animals. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed under inflammatory conditions and may participate in indium-induced carcinogenesis. In this study, we examined 8-nitroG formation in A549 cultured human lung epithelial cells treated with indium compounds, including nanoparticles of indium oxide (In₂O₃) and indium-tin oxide (ITO), and indium chloride (InCl₃). We performed fluorescent immunocytochemistry to examine 8-nitroG formation in indium-exposed A549 cells. All indium compounds significantly increase

SUBMITTER: Ahmed S 

PROVIDER: S-EPMC7329867 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature