Disorganization of chondrocyte columns in the growth plate does not aggravate experimental osteoarthritis in mice.

ABSTRACT: Osteoarthritis (OA) is a multifactorial joint disease mainly affecting articular cartilage (AC) with a relevant biomechanical component. During endochondral ossification growth plate (GP) chondrocytes arrange in columns. GPs do not ossify in skeletally mature rodents. In neonatal mice, an altered joint loading induces GP chondrocyte disorganization. We aimed to study whether experimental OA involves GP disorganization in adult mice and to assess if it may have additional detrimental effects on AC damage. Knee OA was induced by destabilization of the medial meniscus (DMM) in wild-type (WT) adult mice, and in Tamoxifen-inducible Ellis-van-Creveld syndrome protein (Evc) knockouts (Evc^cKO), used as a model of GP disorganization due to Hedgehog signalling disruption. Chondrocyte colu

SUBMITTER: Lamuedra A 

PROVIDER: S-EPMC7329885 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature