Complement Evasion Strategies of Human Pathogenic Bacteria.

ABSTRACT: Human pathogens need to overcome an elaborate network of host defense mechanisms in order to establish their infection, colonization, proliferation and eventual dissemination. The interaction of pathogens with different effector molecules of the immune system results in their neutralization and elimination from the host. The complement system is one such integral component of innate immunity that is critically involved in the early recognition and elimination of the pathogen. Hence, under this immune pressure, all virulent pathogens capable of inducing active infections have evolved immune evasive strategies that primarily target the complement system, which plays an essential and central role for host defense. Recent reports on several bacterial pathogens have elucidated the molecular mec

SUBMITTER: Sharma S 

PROVIDER: S-EPMC7329968 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature