Distinct Functional Connectivity Signatures of Impaired Social Cognition in Multiple Sclerosis.

ABSTRACT: Objective: Multiple sclerosis (MS) is characterized by impairments in basic cognitive functions such as information processing speed as well as in more complex, higher-order domains such as social cognition. However, as these deficits often co-occur, it has remained challenging to determine whether they have a specific pathological basis or are driven by shared biology. Methods: To identify neural signatures of social cognition deficits in MS, data were analyzed from n = 29 patients with relapsing-remitting MS and n = 29 healthy controls matched for age, sex, and education. We used neuropsychological assessments of information processing speed, attention, learning, working memory, and relevant aspects of social cognition (theory of mind, emotion recognition (ER)

SUBMITTER: Golde S 

PROVIDER: S-EPMC7330009 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature