DNA-Mediated Step-Growth Polymerization of Bottlebrush Macromonomers.

ABSTRACT: Herein, we report the DNA-mediated self-assembly of bivalent bottlebrush polymers, a process akin to the step-growth polymerization of small molecule monomers. In these "condensation reactions", the polymer serves as a steric guide to limit DNA hybridization in a fixed direction, while the DNA serves as a functional group equivalent, connecting complementary brushes to form well-defined, one-dimensional nanostructures. The polymerization was studied using spectroscopy, microscopy, and scattering techniques and was modeled numerically. The model made predictions of the degree of polymerization and size distribution of the assembled products, and suggested the potential for branching at hybridization junctions, all of which were confirmed experimentally. This study serves as a theoretical ba

SUBMITTER: Lu X 

PROVIDER: S-EPMC7330103 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature