Human endogenous retrovirus-K mRNA expression and genomic alignment data in hepatoblastoma.

ABSTRACT: Human Endogenous Retroviruses are a class of genomic elements that are the result of ancient retroviral infection of the human germline. Many are biologically active elements that have been implicated in multiple diseases including cancer. The most recent class to invade the human genome is the HERV-K(HML-2) (HERV-K) family. Approximately 90 HERV-K proviruses and many smaller elements have been identified to date in the human genome. Additional proviruses are continually being discovered with the rapid advancement of deep-sequencing and long-read sequencing technologies. HERV-K proviruses are poorly annotated in human transcriptome databases making their analysis in RNA-seq data difficult. To enable analysis, we compiled the sequences of 91 HERV-K proviruses identified in NCBI GenBank (ID

SUBMITTER: Grabski DF 

PROVIDER: S-EPMC7330144 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature