Genomic assessment distinguishes intrapulmonary metastases from synchronous primary lung cancers.

ABSTRACT:

Background

Multiple synchronous lung tumors (MSLT), particularly within a single lobe, represent a diagnostic and treatment challenge. While histologic assessment was once the only method to possibly distinguish multiple primary lung cancers, there is a growing interest in identifying unique genomic features or mutations to best characterize these processes.

Methods

In order to differentiate multiple primary lung malignancies from intrapulmonary metastases in patients with MSLT, we performed whole exome sequencing (WES) on 10 tumor samples from 4 patients with MSLT.

Results

Shared mutations between tumors from the same patient varied from 0-91%. Patient 3 shared no common mutations; however, in Patients 2 and 4, identical mutations were identified among all tumors fro

SUBMITTER: Corsini EM 

PROVIDER: S-EPMC7330333 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature