Tumor infiltrating T cells influence prognosis in stage I-III non-small cell lung cancer.

ABSTRACT:

Background

T cell infiltration in non-small cell lung cancer (NSCLC) is essential for the immunological response to malignant tissue, especially in the era of immune-checkpoint inhibition. To investigate the prognostic impact of CD4⁺ T helper cells (T_h), CD8⁺ cytotoxic (T_c) and FOXP3⁺ regulatory T (T_reg) cells in NSCLC, we performed this analysis.

Methods

By counterstaining of CD4, CD8 and FOXP3 we used immunohistochemistry on tissue microarrays (TMA) to evaluate peritumoral T_h cells, T_reg cells and T_c cells in n=294 NSCLC patients with pTNM stage I-III disease.

Results

Strong CD4⁺ infiltration was associated with higher tumor stages and lymphonodal spread. Ho

SUBMITTER: Schulze AB 

PROVIDER: S-EPMC7330340 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature