The role of ATP in cough hypersensitivity syndrome: new targets for treatment.

ABSTRACT: Clinically, chronic cough can be effectively controlled in most patients by etiological treatment; however, there remain a small number of patients whose cough has unidentifiable etiology or where treatment efficacy is poor following etiology identification, whose condition is described as unexplained chronic cough or refractory chronic cough. Patients with refractory chronic or unexplained chronic cough commonly have increased cough reflex sensitivity, which has been described as cough hypersensitivity syndrome. The adenosine triphosphate (ATP)-gated P2X₃ receptor may be a key link in the activation of sensory neurons that regulate cough reflexes and has recently draw attention as a potential target for the treatment of refractory chronic cough, with a number of clinical studie

SUBMITTER: Zhang M 

PROVIDER: S-EPMC7330343 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature