Spread through air spaces affects survival and recurrence of patients with clinical stage IA non-small cell lung cancer after wedge resection.

ABSTRACT:

Background

Spread through air spaces (STAS) is reportedly a significant risk factor for recurrence and a prognostic factor in patients with non-small cell lung cancer (NSCLC), especially after sublobar resection. Because wedge resection (WR) is associated with insufficient margins, we hypothesized that STAS has a greater prognostic impact in patients who undergo WR compared with segmentectomy. We aimed to clarify the value of STAS as a prognostic factor in patients with NSCLC after WR.

Methods

We evaluated 217 patients with clinical stage IA NSCLC who underwent sublobar resection. The prognostic impact of STAS in these patients was compared between the WR (n=100) and segmentectomy (n=117) cases.

Results

STAS was present in 15.7% of the 217 patients. STAS was a signifi

SUBMITTER: Shiono S 

PROVIDER: S-EPMC7330349 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature