The growth feature and its diagnostic value for benign and malignant pulmonary nodules met in routine clinical practice.

ABSTRACT:

Background

Growth rate is an independent risk factor for lung cancer in screened pulmonary nodules. This study aimed to clarify growth characteristics of pulmonary nodules in routine clinical practice and examine whether volume doubling time (VDT) can predict the malignancy of these nodules.

Methods

We retrospectively enrolled patients with 5-30-mm-sized pulmonary nodules that had been surgically resected after a follow-up of at least 3 months. Two follow-up computed tomography (CT) images with similar thickness and long interval were obtained. Then, three-dimensional (3D) manual segmentation for all nodules was performed on two follow-up CT scans. Subsequently, VDT was calculated for nodules with a change in volume of at least 25%.

Results

Overall, 305 pulmonary nodu

SUBMITTER: Zhang R 

PROVIDER: S-EPMC7330364 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature