Dosimetric analysis of lymphopenia during chemoradiotherapy for esophageal cancer.

ABSTRACT:

Background

Lymphopenia during chemoradiation (CRT) for esophageal cancer (EC) can adversely affect clinical outcomes. We sought to explore an association between lymphopenia and dosimetric parameters during CRT for EC.

Methods

After IRB approval, we retrospectively reviewed 54 patients treated with either definitive or neoadjuvant CRT for EC. Absolute lymphocyte count was recorded weekly during CRT up and graded according to the common terminology of adverse events (CTCAE) version 4.0. Dose volume histograms (DVH) parameters were collected based on vertebral body, body dose, dose to peripheral lymphocytes, and spleen. Logistic regression correlated Grade 4 toxicity with DVH parameters and linear regression analysis correlated absolute lymphocyte nadir counts with DVH paramet

SUBMITTER: Newman NB 

PROVIDER: S-EPMC7330371 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature