Divergent Changes in Serum Branched-Chain Amino Acid Concentrations and Estimates of Insulin Resistance throughout Gestation in Healthy Women.

ABSTRACT:

Background

Branched-chain amino acid (BCAA) concentrations in the blood have been correlated with insulin resistance, but this relation throughout gestation (period in which insulin resistance typically increases) is unclear.

Objective

The objective of this study was to determine the associations between changes in BCAA concentrations and estimates of insulin resistance throughout gestation.

Methods

Serum BCAA (Leu, Ile, Val) concentrations and insulin resistance/sensitivity [i.e., homeostatic model assessment-2 of insulin resistance (HOMA2-IR), estimated metabolic clearance rate (MCR) of glucose, and estimated first- and second-phase insulin responses] were assessed at early (EP; 8.5 ± 0.2 wk) and/or late (LP; 29.2 ± 0.8 wk) pregnancy in 53 healthy women from the Glo

SUBMITTER: Allman BR 

PROVIDER: S-EPMC7330471 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature