Genetic Support for Longevity-Enhancing Drug Targets: Issues, Preliminary Data, and Future Directions.

ABSTRACT: Interventions meant to promote longevity and healthy aging have often been designed or observed to modulate very specific gene or protein targets. If there are naturally occurring genetic variants in such a target that affect longevity as well as the molecular function of that target (eg, the variants influence the expression of the target, acting as "expression quantitative trait loci" or "eQTLs"), this could support a causal relationship between the pharmacologic modulation of the target and longevity and thereby validate the target at some level. We considered the gene targets of many pharmacologic interventions hypothesized to enhance human longevity and explored how many variants there are in those targets that affect gene function (eg, as expression quantitative trait loci). We also

SUBMITTER: McCorrison J 

PROVIDER: S-EPMC7330475 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature