Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons.

ABSTRACT:

Importance

Identifying genes and proteins for cognitive resilience (ie, targets that may be associated with slowing or preventing cognitive decline regardless of the presence, number, or combination of common neuropathologic conditions) provides a complementary approach to developing novel therapeutics for the treatment and prevention of Alzheimer disease and related dementias.

Objective

To identify proteins associated with cognitive resilience via a proteome-wide association study of the human dorsolateral prefrontal cortex.

Design, setting, and participants

This study used data from 391 community-dwelling older persons who participated in the Religious Orders Study and the Rush Memory and Aging Project. The Religious Orders Study began enrollment January 1, 1994, an

SUBMITTER: Yu L 

PROVIDER: S-EPMC7330835 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature