Induced neuroprotection by remote ischemic perconditioning as a new paradigm in ischemic stroke at the acute phase, a systematic review.

ABSTRACT: BACKGROUND:Remote ischemic conditioning during cerebral ischemia (remote ischemic perconditioning, RIPerC) refers to the application of several cycles of brief ischemia and reperfusion (I/R) commonly to a limb, and it represents a new paradigm in neuroprotection with multiple mechanisms of action in ischemic stroke (IS) patients during acute phase. Some clinical trials just finished, and a few others are still ongoing; gather the current knowledge and pull it down to influence the present and future studies was the goal of this paper. METHODS:A systematic review of published research papers and/or registered clinical trials since 2000 was performed. RESULTS:Nineteen studies were identified and only four studies were completed. All of them have demonstrated that RIPerC is safe, feasible and

SUBMITTER: Purroy F 

PROVIDER: S-EPMC7330956 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature