New Tailored RNA-Targeted Organometallic Drug Candidates against Huh7 (Liver) and Du145 (Prostate) Cancer Cell Lines.

ABSTRACT: New organometallic drug candidates [Ph₂Sn(HL)], 1, and [Ru(η⁶--p-cymene)(HL)Cl], 2, were designed and synthesized by in situ reaction of a Schiff base ligand (HL) and diphenyltin dichloride and [RuCl₂(p-cymene)]₂, respectively. The drug candidates 1 and 2 have been characterized by spectroscopic methods (Fourier-transform infrared spectroscopy, UV-vis, and ¹H/¹³C NMR), elemental analysis, and single X-ray crystallographic studies (in case of 1). The ground-state geometry optimization of 1 and 2 was performed by density functional theory calculations. The interaction of 1 and 2 with tRNA was assessed by absorption spectroscopy, cyclic voltammetry, ci

SUBMITTER: Khan HY 

PROVIDER: S-EPMC7331047 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature