Short- and long-term impact of vaccination against cytomegalovirus: a modeling study.

ABSTRACT:

Background

Infection with cytomegalovirus (CMV) is highly prevalent worldwide and can cause severe disease in immunocompromised persons and congenitally infected infants. The disease burden caused by congenital CMV infection is high, especially in resource-limited countries. Vaccines are currently under development for various target groups.

Methods

We evaluated the impact of vaccination strategies and hygiene intervention using transmission models. Model parameters were estimated from a cross-sectional serological population study (n=5179) and a retrospective birth cohort (n=31,484), providing information on the age- and sex-specific CMV prevalence and on the birth prevalence of congenital CMV (cCMV).

Results

The analyses show that vertical transmission and infectiou

SUBMITTER: Rozhnova G 

PROVIDER: S-EPMC7331215 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature