All-trans retinoic acid attenuates the progression of Ang II-induced abdominal aortic aneurysms in ApoE-/-mice.

ABSTRACT: BACKGROUND:To determine whether all-trans retinoic acid (ATRA) can influence the development of Angiotensin II (Ang II) induced experimental abdominal aortic aneurysms (AAAs). METHODS:Apolipoprotein E knock-out (ApoE-/-) mice were randomly assigned to 4 groups. Mice in the AAA and ATRA groups underwent continuous subcutaneous Ang II infusion for 28 days to induce AAA, while the Sham and Control groups were infused with saline. Systolic blood pressure was measured by the tail-cuff technique. The Control and ATRA groups received ATRA treatment. Aortic tissue samples were obtained at 28 days after surgery and evaluated by aortic diameter measurement, Western blotting, immunohistochemistry, and hematoxylin-eosin (H&E) and Verhoeff-Van Gieson (EVG) staining. RESULTS:The abdominal aortic diamete

SUBMITTER: Xiao J 

PROVIDER: S-EPMC7331218 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature