Ileal proteomic changes associated with IL-25-mediated resistance against intestinal trematode infections.

ABSTRACT:

Background

Echinostoma caproni (Trematoda: Echinostomatidae) is an intestinal trematode, which has been extensively used to investigate the factors that determine the rejection of intestinal helminths. In this sense, several studies have shown that IL-25 is critical for the development of resistance against E. caproni in mice. In fact, treatment of mice with recombinant IL-25 generates resistance against primary E. caproni infection. However, the mechanisms by which IL-25 induces resistance remain unknown.

Methods

To study the mechanisms responsible for resistance elicited by IL-25, we analyzed the ileal proteomic changes induced by IL-25 in mice and their potential role in resistance. To this purpose, we compared the protein expression profiles in the ileum of four experime

SUBMITTER: Alvarez-Izquierdo M 

PROVIDER: S-EPMC7331265 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature