HIV-1 subtype C transmitted founders modulate dendritic cell inflammatory responses.

ABSTRACT:

Background

Heterosexual transmission remains the main route of HIV-1 transmission and female genital tract (FGT) inflammation increases the risk of infection. However, the mechanism(s) by which inflammation facilitates infection is not fully understood. In rhesus macaques challenged with simian immunodeficiency virus, dendritic cell (DC) mediated recruitment of CD4+ T cells to the FGT was critical for infection. The aim of this study was to delineate the mechanisms underlying DC-mediated HIV infection by comparing chemokine and pro-inflammatory cytokine production in response to transmitted founder (TF) and chronic infection (CI) Envelope (Env) pseudotyped viruses (PSV).

Results

Monocyte-derived DCs (MDDCs) were stimulated with PSV and recombinant gp140 representing matched

SUBMITTER: Lumngwena EN 

PROVIDER: S-EPMC7331269 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature