A comprehensive methylation signature identifies lymph node metastasis in esophageal squamous cell carcinoma.

ABSTRACT: Treatment modalities in esophageal squamous cell carcinoma (ESCC) depend largely on lymph node metastasis (LNM) status. With suboptimal detection sensitivity of existing imaging techniques, we propose a methylation signature which identifies patients with LNM with greater accuracy. This would allow precise stratification of high-risk patients requiring more aggressive treatment from low-risk ESCC patients who can forego radical surgery. An unbiased genome-wide methylation signature for LNM detection was established from an initial in silico discovery phase. The signature was tested in independent clinical cohorts comprising of 249 ESCC patients. The prognostic potential of the methylation signature was compared to clinical variables including LNM status. A 10-probe LNM associated signature

SUBMITTER: Roy R 

PROVIDER: S-EPMC7331270 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature