The value of nasal nitric oxide measurement in the diagnosis of primary ciliary dyskinesia.

ABSTRACT:

Importance

Nasal nitric oxide (nNO) testing is a method used in the diagnosis of primary ciliary dyskinesia (PCD). It has not been evaluated in Chinese population.

Objective

To establish a reference nNO value to assist in the diagnosis of PCD in Chinese children.

Methods

nNO values were measured in children with PCD (n = 36), cystic fibrosis (CF) (n = 20), asthma (n = 45), post-infectious bronchiolitis obliterans (BO) (n = 41) and non-PCD/non-CF bronchiectasis (n = 32). The receiver operating characteristic nNO value for the diagnosis of PCD was plotted and the area under the curve was calculated.

Results

nNO values were significantly lower in children with PCD (median 25.66 nL/min) than in children with asthma (186.26 ± 58.95

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7331418 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature