Supplemental estrogen and caloric restriction reduce obesity-induced periprostatic white adipose inflammation in mice.

ABSTRACT: Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and worse prognosis for PC patients. Recently, we showed in men that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by macrophages surrounding dead or dying adipocytes forming crown-like structures, was associated with high-grade PC. Possibly, interventions that suppress periprostatic WAT inflammation will improve outcomes for men with PC. Here, we tested the hypothesis that supplemental 17β-estradiol (E2) could decrease periprostatic WAT inflammation in obese male mice. Mice were fed a high-fat diet to induce periprostatic WAT inflammation before being treated with supplemental E2. E2 supplementation suppressed caloric intake, induced weight loss, decreased periprosta

SUBMITTER: Bhardwaj P 

PROVIDER: S-EPMC7331453 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature