Dataset Information

The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.

ABSTRACT:

Background

Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.

Objective

To characterize the diversity of cutaneous manifestations of COVID-19 and facilitate understanding of the underlying pathophysiology.

Methods

Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies.

Results

The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. Of the 171 patients in the registry with laboratory-confirmed COVID-19, the most common morphologies were morbilliform (22%), pernio-like (18%), urticarial (16%), macular erythema (13%), vesicular (11%), papulosquamous (9.9%), and retiform purpura (6.4%). Pernio-like lesions were common in patients with mild disease, whereas retiform purpura presented exclusively in ill, hospitalized patients.

Limitations

We cannot estimate incidence or prevalence. Confirmation bias is possible.

Conclusions

This study highlights the array of cutaneous manifestations associated with COVID-19. Many morphologies were nonspecific, whereas others may provide insight into potential immune or inflammatory pathways in COVID-19 pathophysiology.

SUBMITTER: Freeman EE

PROVIDER: S-EPMC7331510 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.

Freeman Esther E EE McMahon Devon E DE Lipoff Jules B JB Rosenbach Misha M Kovarik Carrie C Desai Seemal R SR Harp Joanna J Takeshita Junko J French Lars E LE Lim Henry W HW Thiers Bruce H BH Hruza George J GJ Fox Lindy P LP

Journal of the American Academy of Dermatology 20200702 4

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.<h4>Objective</h4>To characterize the diversity of cutaneous manifestations of COVID-19 and facilitate understanding of the underlying pathophysiology.<h4>Methods</h4>Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies.<h4>Results</h4>The registry collected 716 cases of new-onset dermatologic symptoms in patients with ...[more]

PMID: 32622888

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Project description:ObjectivesTo provide an overview of the spectrum, characteristics and outcomes of neurologic manifestations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.MethodsWe conducted a single-centre retrospective study during the French coronavirus disease 2019 (COVID-19) epidemic in March-April 2020. All COVID-19 patients with de novo neurologic manifestations were eligible.ResultsWe included 222 COVID-19 patients with neurologic manifestations from 46 centres in France. Median (interquartile range, IQR) age was 65 (53-72) years and 136 patients (61.3%) were male. COVID-19 was severe or critical in 102 patients (45.2%). The most common neurologic diseases were COVID-19-associated encephalopathy (67/222, 30.2%), acute ischaemic cerebrovascular syndrome (57/222, 25.7%), encephalitis (21/222, 9.5%) and Guillain-Barré syndrome (15/222, 6.8%). Neurologic manifestations appeared after the first COVID-19 symptoms with a median (IQR) delay of 6 (3-8) days in COVID-19-associated encephalopathy, 7 (5-10) days in encephalitis, 12 (7-18) days in acute ischaemic cerebrovascular syndrome and 18 (15-28) days in Guillain-Barré syndrome. Brain imaging was performed in 192 patients (86.5%), including 157 magnetic resonance imaging (70.7%). Among patients with acute ischaemic cerebrovascular syndrome, 13 (22.8%) of 57 had multiterritory ischaemic strokes, with large vessel thrombosis in 16 (28.1%) of 57. Brain magnetic resonance imaging of encephalitis patients showed heterogeneous acute nonvascular lesions in 14 (66.7%) of 21. Cerebrospinal fluid of 97 patients (43.7%) was analysed, with pleocytosis found in 18 patients (18.6%) and a positive SARS-CoV-2 PCR result in two patients with encephalitis. The median (IQR) follow-up was 24 (17-34) days with a high short-term mortality rate (28/222, 12.6%).ConclusionsClinical spectrum and outcomes of neurologic manifestations associated with SARS-CoV-2 infection were broad and heterogeneous, suggesting different underlying pathogenic processes.

Dataset Information

The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.

Background

Objective

Methods

Results

Limitations

Conclusions

Publications

The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.

Similar Datasets

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