Macrophages are the primary effector cells in IL-7-induced arthritis.

ABSTRACT: Synovial macrophages are crucial in the development of joint inflammation and bone damage; however, the pathways that control macrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined that elevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highly responsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), and tumor necrosis factor-α (TNFα), the classic M1 macrophage mediators, enhance IL-7R expression in RA and murine macrophages. The local expression of IL-7 provokes arthritis, predominantly through escalating the number of F480⁺iNOS⁺ cells rather than CD3⁺ T cells. E

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC7331600 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature