Effects of repetitive Iodine thyroid blocking on the foetal brain and thyroid in rats: a systems biology approach.

ABSTRACT: A single administration of an iodine thyroid blocking agent is usually sufficient to protect thyroid from radioactive iodine and prevent thyroid cancer. Repeated administration of stable iodine (rKI) may be necessary during prolonged or repeated exposure to radioactive iodine. We previously showed that rKI for eight days offers protection without toxic effects in adult rats. However, the effect of rKI administration in the developing foetus is unknown, especially on brain development, although a correlation between impaired maternal thyroid status and a decrease in intelligence quotient of the progeny has been observed. This study revealed distinct gene expression profiles between the progeny of rats receiving either rKI or saline during pregnancy. To understand the implication of these di

SUBMITTER: Cohen DPA 

PROVIDER: S-EPMC7331645 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature