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The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4⁺ T cell depletion and enterocyte damage.

ABSTRACT: The intesinal microbiome is considered important in human immunodeficiency virus (HIV) pathogenesis and therefore represents a potential therapeutic target to improve the patients' health status. Longitudinal alterations in the colonic mucosa-associated microbiome during simian immunodeficiency virus (SIV) infection were investigated using a 16S rRNA amplicon approach on the Illumina sequencing platform and bioinformatics analyses. Following SIV infection of six animals, no alterations in microbial composition were observed before the viral load peaked in the colon. At the time of acute mucosal SIV replication, the phylum Bacteroidetes including the Bacteroidia class as well as the phylum Firmicutes and its families Ruminococcaceae and Eubacteriaceae became more abundant. Enrichment of Bac

SUBMITTER: Allers K

PROVIDER: S-EPMC7331662 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Dataset Information

The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4⁺ T cell depletion and enterocyte damage.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4+ T cell depletion and enterocyte damage.

OmicsDI is part of the ELIXIR infrastructure

Tweets

The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4⁺ T cell depletion and enterocyte damage.