An important role of PHRF1 in dendritic architecture and memory formation by modulating TGF-β signaling.

ABSTRACT: PHRF1 is involved in transforming growth factor β (TGF-β) signaling to constrain the formation of acute promyelocytic leukemia (APL) in mouse APL models. PHRF1 also participates in modulating non-homologous end-joining. However, the role of PHRF1 in mammalian dendrite architecture and synaptic plasticity is unclear. Here, we investigated the role of PHRF1 in dendritic formation in the murine hippocampus using Camk2a promoter driven-iCre recombinase to conduct a PHRF1 conditional knockout, namely PHRF1^Δ/Δ, in the forebrain region. PHRF1^Δ/Δ mice developed normally, but exhibited anxiety-like behaviors and displayed defective spatial memory. Alterations of dendritic complexity in apical and basal dendrites of pyramidal neurons were noticed in PHRF1^Δ/Δ mutants.

SUBMITTER: Shih TW 

PROVIDER: S-EPMC7331665 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature