Integrated network modeling approach defines key metabolic responses of soil microbiomes to perturbations.

ABSTRACT: The soil environment is constantly changing due to shifts in soil moisture, nutrient availability and other conditions. To contend with these changes, soil microorganisms have evolved a variety of ways to adapt to environmental perturbations, including regulation of gene expression. However, it is challenging to untangle the complex phenotypic response of the soil to environmental change, partly due to the absence of predictive modeling frameworks that can mechanistically link molecular-level changes in soil microorganisms to a community's functional phenotypes (or metaphenome). Towards filling this gap, we performed a combined analysis of metabolic and gene co-expression networks to explore how the soil microbiome responded to changes in soil moisture and nutrient conditions and to determ

SUBMITTER: McClure RS 

PROVIDER: S-EPMC7331712 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature