Functional organization of mouse primary auditory cortex in adult C57BL/6 and F1 (CBAxC57) mice.

ABSTRACT: The primary auditory cortex (A1) plays a key role for sound perception since it represents one of the first cortical processing stations for sounds. Recent studies have shown that on the cellular level the frequency organization of A1 is more heterogeneous than previously appreciated. However, many of these studies were performed in mice on the C57BL/6 background which develop high frequency hearing loss with age making them a less optimal choice for auditory research. In contrast, mice on the CBA background retain better hearing sensitivity in old age. Since potential strain differences could exist in A1 organization between strains, we performed comparative analysis of neuronal populations in A1 of adult (~ 10 weeks) C57BL/6 mice and F1 (CBAxC57) mice. We used in vivo 2-photon imaging of

SUBMITTER: Bowen Z 

PROVIDER: S-EPMC7331716 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature