The effects of intramuscular administration of scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled trial.

ABSTRACT:

Introduction

Major depressive disorder (MDD) is a common affective disorder. Currently established pharmacotherapies lack rapid clinical response, thereby limiting their ability to bring instant relief to patients. A series of clinical trials has demonstrated the antidepressant effects of scopolamine, yet few have studied the effects of add-on scopolamine to currently available antidepressants. It is not known whether conventional antidepressant treatment with a 3-day scopolamine injection could speed up oral antidepressant efficacy. The main focus of this study is to detect the capacity of the rapid-onset efficacy of such a treatment option.

Methods and analysis

This study consisted of a single-centre, double-blind, three-arm randomized trial with a 4-week follow-up period.

SUBMITTER: Zhou J 

PROVIDER: S-EPMC7331769 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature