Sulfation modulates the targeting properties of hyaluronic acid to P-selectin and CD44.
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ABSTRACT:
SUBMITTER: Bhattacharya DS
PROVIDER: S-EPMC7331950 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Sulfation modulates the targeting properties of hyaluronic acid to P-selectin and CD44.
Bhattacharya Deep S DS Svechkarev Denis D Bapat Aishwarya A Patil Prathamesh P Hollingsworth Michael A MA Mohs Aaron M AM
ACS biomaterials science & engineering 20200504 6
Many targeting strategies can be employed to direct nanoparticles to tumors for imaging and therapy. However, tumors display a dynamic, heterogeneous microenvironment that undergoes spatiotemporal changes, including the expression of targetable cell-surface biomarkers. Here, we develop a nanoparticle system to effectively target two receptors overexpressed in the microenvironment of aggressive tumors. Hyaluronic acid (HA) was regioselectivity modified using a multi-step synthetic approach to alt ...[more]
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