A kinetic mechanism for enhanced selectivity of membrane transport.

ABSTRACT: Membrane transport is generally thought to occur via an alternating access mechanism in which the transporter adopts at least two states, accessible from two different sides of the membrane to exchange substrates from the extracellular environment and the cytoplasm or from the cytoplasm and the intracellular matrix of the organelles (only in eukaryotes). In recent years, a number of high resolution structures have supported this general framework for a wide class of transport molecules, although additional states along the transport pathway are emerging as critically important. Given that substrate binding is often weak in order to enhance overall transport rates, there exists the distinct possibility that transporters may transport the incorrect substrate. This is certainly the case for m

SUBMITTER: Bisignano P 

PROVIDER: S-EPMC7331977 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature