Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study.

ABSTRACT:

Background

Since screening programs identify only a small proportion of the population as eligible for an intervention, genomic prediction of heritable risk factors could decrease the number needing to be screened by removing individuals at low genetic risk. We therefore tested whether a polygenic risk score for heel quantitative ultrasound speed of sound (SOS)-a heritable risk factor for osteoporotic fracture-can identify low-risk individuals who can safely be excluded from a fracture risk screening program.

Methods and findings

A polygenic risk score for SOS was trained and selected in 2 separate subsets of UK Biobank (comprising 341,449 and 5,335 individuals). The top-performing prediction model was termed "gSOS", and its utility in fracture risk screening was tested in 5

SUBMITTER: Forgetta V 

PROVIDER: S-EPMC7331983 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature