Chronic kidney disease in cats alters response of the plasma metabolome and fecal microbiome to dietary fiber.

ABSTRACT:

Methods

A cross-over study within a split-plot design was performed using healthy (n = 10) and CKD cats [IRIS Stage 1 and 2; n = 10]. Cats were fed dry Prescription Diet® k/d® Feline with chicken, during a pre-trial period and then randomly assigned to two fiber treatments for 4 weeks each. Treatment foods were formulated similar to pre-trial food, with the exception that they contained 0.500% betaine, 0.586% oat beta glucan, and either 0.407% short chain fructooligosaccharides (scFOS) fiber or 3.44% apple pomace. Both foods had similar crude fiber percent (2.0 and 2.1% for scFOS and apple pomace, respectively) whereas soluble fiber was 0.8 and 1.6%, respectively.

Results

Plasma metabolites separated cats based on health status. At baseline, cats with CKD had significantly h

SUBMITTER: Hall JA 

PROVIDER: S-EPMC7331996 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature