Elevated plasma cotinine is associated with an increased risk of developing IBD, especially among users of combusted tobacco.

ABSTRACT: OBJECTIVE:Smoking has previously been associated with inflammatory bowel disease (IBD), but no study has reported on cotinine, an objective, biochemical measure of tobacco use. We aimed at testing the hypothesis that cotinine levels among healthy subjects are associated with an increased risk of developing IBD in later life. DESIGN:We analysed plasma cotinine and evaluated corresponding lifestyle questionnaires that included tobacco habits in subjects (n = 96) who later developed late-onset IBD (70 ulcerative colitis (UC) and 26 Crohn's disease (CD)) and in sex and age-matched controls (n = 191). RESULTS:Patients who later developed IBD had significantly higher plasma cotinine levels compared to controls. In multivariable analysis, higher log-cotinine was associated with a higher risk of d

SUBMITTER: Widbom L 

PROVIDER: S-EPMC7332008 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature