History of breastfeeding but not mode of delivery shapes the gut microbiome in childhood.

ABSTRACT:

Background

The naïve neonatal gut is sensitive to early life experiences. Events during this critical developmental window may have life-long impacts on the gut microbiota. Two experiences that have been associated with variation in the gut microbiome in infancy are mode of delivery and feeding practices (eg, breastfeeding). It remains unclear whether these early experiences are responsible for microbial differences beyond toddlerhood.

Aims

Our study examined whether mode of delivery and infant feeding practices are associated with differences in the child and adolescent microbiome.

Design, subjects, measures

We used an adoption-sibling design to compare genetically related siblings who were reared together or apart. Gut microbiome samples were collected from 73 child

SUBMITTER: Cioffi CC 

PROVIDER: S-EPMC7332026 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature